SOX2 Regulates YAP1 to Maintain Stemness and Determine Cell Fate in the Osteo-Adipo Lineage
نویسندگان
چکیده
منابع مشابه
SOX2 regulates YAP1 to maintain stemness and determine cell fate in the osteo-adipo lineage.
The osteoblastic and adipocytic lineages arise from mesenchymal stem cells (MSCs), but few regulators of self-renewal and early cell-fate decisions are known. Here, we show that the Hippo pathway effector YAP1 is a direct target of SOX2 and can compensate for the self-renewal defect caused by SOX2 inactivation in osteoprogenitors and MSCs. Osteogenesis is blocked by high SOX2 or YAP1, accelerat...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2013
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2013.05.029